FRAX 597

Name: FRAX 597
Brand: Tocris Bioscience
SKU: 6029

Tocris Bioscience, part of Bio-Techne | Catalog # 6029

Citations (12)

COA / SDS

Potent group I PAK inhibitor

Key Product Details

Description:	Potent group I PAK inhibitor
Chemical Name:	6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	558.1

View Full Technical Details for FRAX 597

Technical Data
Citations

Biological Activity for FRAX 597

FRAX 597 is a potent group I PAK inhibitor (IC₅₀ values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). FRAX 597 exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC₅₀ >10 μM for PAK4). FRAX 597 inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.

Compound Libraries for FRAX 597

FRAX 597 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for FRAX 597

M. Wt	558.1
Formula	C₂₉H₂₈ClN₇OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1286739-19-2
PubChem ID	70934541
InChi Key	DHUJCQOUWQMVCG-UHFFFAOYSA-N
Smiles	CN(CC1)CCN1C2=CC=C(NC3=NC(N(CC)C(C(C4=CC=C(C5=CN=CS5)C=C4Cl)=C6)=O)=C6C=N3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FRAX 597

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.16	20

Preparing Stock Solutions for FRAX 597

The following data is based on the product molecular weight 558.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.96 mL	44.79 mL	89.59 mL
1 mM	1.79 mL	8.96 mL	17.92 mL
2 mM	0.90 mL	4.48 mL	8.96 mL
10 mM	0.18 mL	0.90 mL	1.79 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for FRAX 597

References are publications that support the biological activity of the product.

Yeo FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcit. BMC Cancer 2016 PMID: 26774265
Licciulli FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J.Biol.Chem. 2013 PMID: 23960073