FSEN 1

Name: FSEN 1
Brand: Tocris Bioscience
SKU: 7941

Tocris Bioscience, part of Bio-Techne | Catalog # 7941

COA / SDS

Induces ferroptosis; inhibits FSP1

Key Product Details

Description:	Induces ferroptosis; inhibits FSP1
Chemical Name:	3-(4-Bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole
Purity:	≥98% (HPLC)
Molecular Weight:	484.42

View Full Technical Details for FSEN 1

Technical Data
Citations

Biological Activity for FSEN 1

FSEN 1 is a ferroptosis suppressor protein 1 (FSP1) inhibitor (IC₅₀ = 313 nM). FSEN 1 sensitizes lung cancer cells and organoids to ferroptosis (EC₅₀ = 69 nM) through inhibition of FSP1. Inhibits FSP1 CoQ1 oxidoreductase activity (IC₅₀ = 688 nM).

Technical Data for FSEN 1

M. Wt	484.42
Formula	C₂₂H₂₂BrN₅OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	862808-01-3
PubChem ID	22583648
InChi Key	JGXIXBKKDUNARN-UHFFFAOYSA-N
Smiles	BrC1=CC=C(C2=NN=C3SC(CN4CCN(CC4)C5=CC=C(C=C5)OC)=CN32)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FSEN 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.69	20

Preparing Stock Solutions for FSEN 1

The following data is based on the product molecular weight 484.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.32 mL	51.61 mL	103.22 mL
1 mM	2.06 mL	10.32 mL	20.64 mL
2 mM	1.03 mL	5.16 mL	10.32 mL
10 mM	0.21 mL	1.03 mL	2.06 mL

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References for FSEN 1

References are publications that support the biological activity of the product.

Hendricks Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem.Biol. 2023 PMID: 37178691