FTIDC

Name: FTIDC
Brand: Tocris Bioscience
SKU: 5000

Tocris Bioscience, part of Bio-Techne | Catalog # 5000

Citations (144)

COA / SDS

Potent and selective negative allosteric modulator of mGlu1 receptors; also mGlu1 inverse agonist

Key Product Details

Description:	Potent and selective negative allosteric modulator of mGlu₁ receptors; also mGlu₁ inverse agonist
Chemical Name:	4-[1-(2-Fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-3,6-dihydro-N-methyl-N-(1-methylethyl)-1(2H)-pyridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	358.41

View Full Technical Details for FTIDC

Technical Data
Citations

Biological Activity for FTIDC

FTIDC is a potent and selective mGlu₁ receptor negative allosteric modulator (IC₅₀ values are 5.8 and 6200 nM for mGlu₁ and mGlu₅ respectively). Also acts as an mGlu₁ receptor inverse agonist (IC₅₀ = 7 nM) in the absence of ligand. Exhibits no effect at group II/III mGlu receptors. Inhibits L-glutamate-induced increases in intracellular calcium in mGlu₁-expressing CHO cells. Inhibits nociceptive behavior, and exhibits anxiolytic and antipsychotic effects in vivo. Orally active.

Technical Data for FTIDC

M. Wt	358.41
Formula	C₁₈H₂₃FN₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	873551-53-2
PubChem ID	11245287
InChi Key	CJTLKLBSIFQKNT-UHFFFAOYSA-N
Smiles	O=C(N(C(C)C)C)N1CC=C(C2=C(C)N(C3=C(F)N=CC=C3)N=N2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FTIDC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.84	100

Preparing Stock Solutions for FTIDC

The following data is based on the product molecular weight 358.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.95 mL	27.90 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for FTIDC

References are publications that support the biological activity of the product.

Ito Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist. Bioorg.Med.Chem. 2008 PMID: 18849168
Satow Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allost J.Pharmacol.Exp.Ther. 2008 PMID: 18487514
Suzuki Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1( J.Pharmacol.Exp.Ther. 2007 PMID: 17360958