Furamidine dihydrochloride

Name: Furamidine dihydrochloride
Brand: Tocris Bioscience
SKU: 5202

Tocris Bioscience, part of Bio-Techne | Catalog # 5202

Citations (4)

COA / SDS

Selective PRMT1 inhibitor

Key Product Details

Description:	Selective PRMT1 inhibitor
Chemical Name:	4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	377.27

View Full Technical Details for Furamidine dihydrochloride

Technical Data
Citations

Biological Activity for Furamidine dihydrochloride

Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC₅₀ values are 166, 283 and >400 μM respectively). Inhibits tyrosyl-DNA phosphodiesterase 1 (TDP-1) (IC₅₀ = 1.2 μM). Inhibits cell proliferation in leukemia cell lines, suppresses neuroblastoma tumor growth, and reduces mis-splicing in in vitro and in vivo models of myotonic dystrophy type 1. Also shows dose-dependent inhibition of platelet aggregation (IC50 = 14.8 uM). Cell-permeable.

Compound Libraries for Furamidine dihydrochloride

Furamidine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Furamidine dihydrochloride

M. Wt	377.27
Formula	C₁₈H₁₆N₄O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	55368-40-6
PubChem ID	462428
InChi Key	VXNYQUQHOUERTR-UHFFFAOYSA-N
Smiles	NC(C(C=C3)=CC=C3C1=CC=C(C2=CC=C(C(N)=N)C=C2)O1)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Furamidine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	18.86	50
	DMSO	18.86	50

Preparing Stock Solutions for Furamidine dihydrochloride

The following data is based on the product molecular weight 377.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.30 mL	26.51 mL	53.01 mL
2.5 mM	1.06 mL	5.30 mL	10.60 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
25 mM	0.11 mL	0.53 mL	1.06 mL

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References for Furamidine dihydrochloride

References are publications that support the biological activity of the product.

Marsden Inhibition of arginine methylation impairs platelet function. ACS Pharmacol.Transl.Sci. 2021 PMID: 34661075
Jenquin Furamidine rescues myotonic dystrophy type I associated mis-splicing through multiple mechanisms. ACS Chem.Biol. 2018 PMID: 30118588
Hua PRMT1 promotes neuroblastoma cell survival through ATF5. Oncogenesis 2020 PMID: 32415090
Yan Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J.Med.Chem. 2014 PMID: 24564570