FX 1

Name: FX 1
Brand: Tocris Bioscience
SKU: 6323

Tocris Bioscience, part of Bio-Techne | Catalog # 6323

COA / SDS

Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors

Key Product Details

Description:	Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
Chemical Name:	(5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	368.82

View Full Technical Details for FX 1

Technical Data
Citations

Biological Activity for FX 1

FX 1 is a Bcl-6 inhibitor (K_d = 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft.

Technical Data for FX 1

M. Wt	368.82
Formula	C₁₄H₉ClN₂O₄S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1426138-42-2
PubChem ID	66488970
InChi Key	VISHSGZPGQKEFX-KHPPLWFESA-N
Smiles	OC(CCN1C(S/C(C1=O)=C2C(NC3=CC=C(C=C\23)Cl)=O)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FX 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.88	100

Preparing Stock Solutions for FX 1

The following data is based on the product molecular weight 368.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.56 mL	27.11 mL
5 mM	0.54 mL	2.71 mL	5.42 mL
10 mM	0.27 mL	1.36 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for FX 1

References are publications that support the biological activity of the product.

Cardenas The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clin.Cancer Res. 2017 PMID: 27881582
Cardenas Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J.Clin.Invest. 2016 PMID: 27482887