G418 disulfate salt

Name: G418 disulfate salt
Brand: Tocris Bioscience
SKU: 4131
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4131

(1)

Citations (6)

COA / SDS

Aminoglycoside antibiotic; used in cell culture

Key Product Details

Description:	Aminoglycoside antibiotic; used in cell culture
Molecular Weight:	692.71

View Full Technical Details for G418 disulfate salt

Technical Data
Citations / Reviews (1)

Biological Activity for G418 disulfate salt

G418 disulfate salt is an aminoglycosidic antibiotic. Inhibits protein synthesis in both prokaryotic and eukaryotic cells. Used for selection of eukaryotic cells transfected with the neo gene.

This product has been cell culture tested.

Technical Data for G418 disulfate salt

M. Wt	692.71
Formula	C₂₀H₄₀N₄O₁₀.2H₂SO₄
Storage	Store at +4°C
CAS Number	108321-42-2
PubChem ID	206347
InChi Key	UHEPSJJJMTWUCP-DHDYTCSHSA-N
Smiles	N[C@H]1[C@H](O[C@]2([H])[C@H](O)[C@@H](NC)[C@@](C)(O)CO2)[C@@H](O)[C@H](O[C@]3([H])[C@H](N)[C@@H](O)[C@H](O)[C@]([C@H](O)C)([H])O3)[C@@H](N)C1.OS(O)(=O)=O.OS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for G418 disulfate salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	51.95	75

Preparing Stock Solutions for G418 disulfate salt

The following data is based on the product molecular weight 692.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	1.92 mL	9.62 mL	19.25 mL
3.75 mM	0.38 mL	1.92 mL	3.85 mL
7.5 mM	0.19 mL	0.96 mL	1.92 mL
37.5 mM	0.04 mL	0.19 mL	0.38 mL

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Reconstitution Calculator

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References for G418 disulfate salt

References are publications that support the biological activity of the product.

Bar-Nun G-418, an elongation inhibitor of 80 S ribosomes. Biochim.Biophys.Acta. 1983 PMID: 6193810
Burke and Mogg Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromo. Nucleic Acids Res. 1985 PMID: 2995924
Wagman Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation and preliminary characterization. Antimicrob.Agents Chemother. 1974 PMID: 15828184