Gadolinium chloride

Name: Gadolinium chloride
Brand: Tocris Bioscience
SKU: 4741
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4741

(1)

Citations (9)

COA / SDS

Stretch-activated calcium channel blocker; calcium-sensing receptor agonist

Key Product Details

Description:	Stretch-activated calcium channel blocker; calcium-sensing receptor agonist
Molecular Weight:	263.61

View Full Technical Details for Gadolinium chloride

Technical Data
Citations / Reviews (1)

Biological Activity for Gadolinium chloride

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.

Technical Data for Gadolinium chloride

M. Wt	263.61
Formula	GdCl₃
Storage	Desiccate at RT
CAS Number	10138-52-0
PubChem ID	61486
InChi Key	MEANOSLIBWSCIT-UHFFFAOYSA-K
Smiles	Cl[Gd](Cl)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gadolinium chloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	26.36	100

Preparing Stock Solutions for Gadolinium chloride

The following data is based on the product molecular weight 263.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.79 mL	18.97 mL	37.93 mL
5 mM	0.76 mL	3.79 mL	7.59 mL
10 mM	0.38 mL	1.90 mL	3.79 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

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References for Gadolinium chloride

References are publications that support the biological activity of the product.

Nagata The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 2008 PMID: 18162548
Lee The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca²⁺ and cAMP. Nature 2012 PMID: 23143333
Del Favero The stretch-activated channel blocker Gd³⁺ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 2012 PMID: 22900474
Nishitani Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 2011 PMID: 22053183