Gallein

Name: Gallein
Brand: Tocris Bioscience
SKU: 3090
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3090

(1)

Citations (99)

COA / SDS

Inhibitor of Gβ/γ signaling

Key Product Details

Description:	Inhibitor of G_β/γ signaling
Chemical Name:	3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one
Purity:	≥97%
Molecular Weight:	364.31

View Full Technical Details for Gallein

Technical Data
Citations / Reviews (1)

Biological Activity for Gallein

Gallein is an inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.

Technical Data for Gallein

M. Wt	364.31
Formula	C₂₀H₁₂O₇
Storage	Store at -20°C
Purity	≥97%
CAS Number	2103-64-2
PubChem ID	73685
InChi Key	PHLYOKFVXIVOJC-UHFFFAOYSA-N
Smiles	OC1=CC=C(C(C(C=CC=C5)=C5C(O4)=O)4C(C=CC(O)=C3O)=C3O2)C2=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gallein

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.32	75
	ethanol	3.64	10

Preparing Stock Solutions for Gallein

The following data is based on the product molecular weight 364.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.66 mL	18.30 mL	36.60 mL
3.75 mM	0.73 mL	3.66 mL	7.32 mL
7.5 mM	0.37 mL	1.83 mL	3.66 mL
37.5 mM	0.07 mL	0.37 mL	0.73 mL

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References for Gallein

References are publications that support the biological activity of the product.

Ukhanov Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J.Neurosci. 2011 PMID: 21209212
Lehmann Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol.Pharmacol. 2008 PMID: 18006643