GeA-69

Name: GeA-69
Brand: Tocris Bioscience
SKU: 6795

Tocris Bioscience, part of Bio-Techne | Catalog # 6795

COA / SDS

Selective allosteric PARP14 inhibitor

Key Product Details

Description:	Selective allosteric PARP14 inhibitor
Chemical Name:	N-[2-(9H-Carbazol-1-yl)phenyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	300.35

View Full Technical Details for GeA-69

Technical Data
Citations

Biological Activity for GeA-69

GeA-69 is a selective allosteric inhibitor of poly (ADP-ribose) polymerase 14 (PARP14) macrodomain 2 (MD2) (IC₅₀ = 720 nM, K_d = 860 nM). It inhibits adenosine diphosphate ribose (ADPR) binding to the macrodomain 2 of PARP14 and prevents PARP14 MD2 localization to DNA damage sites in intact cells. GeA-69 is highly cell permeable.

Technical Data for GeA-69

M. Wt	300.35
Formula	C₂₀H₁₆N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2143475-98-1
PubChem ID	135397654
InChi Key	LDPDVNYCIOHPGF-UHFFFAOYSA-N
Smiles	O=C(NC=1C=CC=CC1C=2C=CC=C3C=4C=CC=CC4NC23)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GeA-69

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.03	100
	ethanol	15.02	50

Preparing Stock Solutions for GeA-69

The following data is based on the product molecular weight 300.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.33 mL	16.65 mL	33.29 mL
5 mM	0.67 mL	3.33 mL	6.66 mL
10 mM	0.33 mL	1.66 mL	3.33 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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Reconstitution Calculator

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References for GeA-69

References are publications that support the biological activity of the product.

Moustakim Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorg.Med.Chem. 2018 PMID: 29567296
Schuller Discovery of a selective allosteric inhibitor targeting macrodomain 2 of polyadenosine-diphosphate-ribose polymerase 14. ACS Chem.Biol. 2017 PMID: 28991428