Genistein

Name: Genistein
Brand: Tocris Bioscience
SKU: 1110

Tocris Bioscience, part of Bio-Techne | Catalog # 1110

Citations (67)

COA / SDS

EGFR kinase inhibitor. Also estrogen and PPARγ ligand

Key Product Details

Description:	EGFR kinase inhibitor. Also estrogen and PPARγ ligand
Chemical Name:	5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	270.24

View Full Technical Details for Genistein

Technical Data
Citations

Biological Activity for Genistein

Genistein is a phytoestrogen with a wide range of biological actions. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase, binds to PPARγ and estrogen receptors and acts as an agonist at GPER. Genistein inhibits aggregation and fibrilization of Aβ₄₂ and amylin₃₇ (hiAPP). In Huntington's disease fibroblast cells, Genistein reduces intracellular mutant huntingtin (mHTT) aggregates and induces degradation of mHTT; in a cellular model of Huntington's disease, Genistein corrects the mutant phenotype through stimulation of autophagy.

Compound Libraries for Genistein

Genistein is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Genistein

M. Wt	270.24
Formula	C₁₅H₁₀O₅
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	446-72-0
PubChem ID	5280961
InChi Key	TZBJGXHYKVUXJN-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=C1)C1=COC2=C(C(O)=CC(O)=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Genistein

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for Genistein

The following data is based on the product molecular weight 270.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.70 mL	18.50 mL	37.00 mL
5 mM	0.74 mL	3.70 mL	7.40 mL
10 mM	0.37 mL	1.85 mL	3.70 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for Genistein

References are publications that support the biological activity of the product.

Pierzynowska Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington's disease patients. Metab.Brain Dis. 2019 PMID: 30850940
Ren Genistein: A Dual Inhibitor of Both Amyloid β and Human Islet Amylin Peptides. ACS.Chem.Neurosci. 2018 PMID: 29432676
Migita Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors. J.Immunol. 1994 PMID: 7523495
Linassier Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity. Biochem.Pharmacol. 1990 PMID: 2153378
Dang Peroxisome proliferator-activated receptor γ (PPARγ) as a molecular target for the soy phytoestrogen genistein. J.Biol.Chem. 2003 PMID: 12421816
Akiyama Genistein, a specific inhibitor of tyrosine-specific protein kinases. J.Biol.Chem. 1987 PMID: 3106339