GGsTop

Name: GGsTop
Brand: Tocris Bioscience
SKU: 4452

Tocris Bioscience, part of Bio-Techne | Catalog # 4452

Citations (7)

COA / SDS

Inhibitor of γ-glutamyl transpeptidase (GGT)

Key Product Details

Chemical Name:	3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneacetic acid
Purity:	≥95%

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Technical Data
Citations

Biological Activity for GGsTop

GGsTop is a selective, irreversible γ-glutamyl transpeptidase (GGT) inhibitor; displays no inhibitory effects on glutamine amidotransferases or asparagine synthetase. Suppresses oxidative stress by inhibiting GGT activation. Prevents ischemia/reperfusion-induced acute kidney injury in rats in vivo.

Technical Data for GGsTop

Formula	C₁₃H₁₈NO₇P
Storage	Store at -20°C
Purity	≥95%
CAS Number	926281-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GGsTop

Solubility

Soluble Soluble to 20 mM in water and to 50 mM in DMSO

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References for GGsTop

References are publications that support the biological activity of the product.

Han et al. Design, synthesis, and evaluation of γ-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of γ-glutamyl transpeptidase. Biochemistry, 2007;46:1432 PMID: 17260973
Yamamoto et al. Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats. J.Pharmacol.Exp.Ther., 2011;339:945 PMID: 21937737

GGsTop

Tocris Bioscience, part of Bio-Techne | Catalog # 4452

Key Product Details

Biological Activity for GGsTop

Technical Data for GGsTop

Solubility for GGsTop

Dilution Calculator

Reconstitution Calculator

References for GGsTop

Product Documents for GGsTop

COA

Certificate of Analysis

SDS

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