GGTI 298

Name: GGTI 298
Brand: Tocris Bioscience
SKU: 2430
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2430

(1)

Citations (25)

COA / SDS

Geranylgeranyltransferase I (GGTase I) inhibitor

Key Product Details

Description:	Geranylgeranyltransferase I (GGTase I) inhibitor
Chemical Name:	N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt
Purity:	≥95% (HPLC)
Molecular Weight:	593.66

View Full Technical Details for GGTI 298

Technical Data
Citations / Reviews (1)

Biological Activity for GGTI 298

GGTI 298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC₅₀ values are 3 and > 10 μM respectively). Causes G₀-G₁ cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.

Technical Data for GGTI 298

M. Wt	593.66
Formula	C₂₇H₃₃N₃O₃S.CF₃CO₂H
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1217457-86-7
PubChem ID	16078971
InChi Key	WALKWJPZELDSKT-UFABNHQSSA-N
Smiles	SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](OC)=O)CC(C)C)=O)C(C2=CC=CC3=C2C=CC=C3)=C1.FC(F)(C(O)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GGTI 298

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	14.84	25

Preparing Stock Solutions for GGTI 298

The following data is based on the product molecular weight 593.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	6.74 mL	33.69 mL	67.38 mL
1.25 mM	1.35 mL	6.74 mL	13.48 mL
2.5 mM	0.67 mL	3.37 mL	6.74 mL
12.5 mM	0.13 mL	0.67 mL	1.35 mL

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References for GGTI 298

References are publications that support the biological activity of the product.

Kusama Selective inhibition of cancer cell invasion by a geranylgeranyltransferase inhibitor. Clin.Exp.Meta.
Miquel GGTI-298 induces G0-G1 block and apoptosis whereas FTI-227 causes G2-M enrichment in A549 cells. Cancer Res. 1997 PMID: 9157972
Porcu A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics. Mol.Cancer 2010 PMID: 20653956
McGuire Platelet-derived growth factor receptor tyrosine kinase phosphorylation requires protein geranylgeranylation but not farnesylation. J.Biol.Chem. 1996 PMID: 8910319