GGTI 298

Name: GGTI 298
Brand: Tocris Bioscience
SKU: 2430

Tocris Bioscience, part of Bio-Techne | Catalog # 2430

(1)

Citations (25)

COA / SDS

Geranylgeranyltransferase I (GGTase I) inhibitor

Key Product Details

Chemical Name:	N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt
Purity:	≥95%
Molecular Weight:	593.66 kDa

View Full Technical Details for GGTI 298

Technical Data
Citations / Reviews (1)

Biological Activity for GGTI 298

GGTI 298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC₅₀ values are 3 and > 10 μM respectively). Causes G₀-G₁ cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.

Technical Data for GGTI 298

M. Wt	593.66 kDa
Formula	C₂₇H₃₃N₃O₃S.CF₃CO₂H
Storage	Store at -20°C
Purity	≥95%
CAS Number	1217457-86-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GGTI 298

Solubility

Soluble Soluble to 25 mM in DMSO

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References for GGTI 298

References are publications that support the biological activity of the product.

McGuire et al. Platelet-derived growth factor receptor tyrosine kinase phosphorylation requires protein geranylgeranylation but not farnesylation. J.Biol.Chem., 1996;271:27402 PMID: 8910319
Miquel et al. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-227 causes G2-M enrichment in A549 cells. Cancer Res., 1997;57:1846 PMID: 9157972
Porcu et al. A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics. Mol.Cancer, 2010;9:197 PMID: 20653956
Kusama et al. Selective inhibition of cancer cell invasion by a geranylgeranyltransferase inhibitor. Clin.Exp.Meta., 2003;20:561