GI 530159

Name: GI 530159
Brand: Tocris Bioscience
SKU: 6689

Tocris Bioscience, part of Bio-Techne | Catalog # 6689

COA / SDS

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator

Key Product Details

Description:	K_2P2.1 (TREK-1) and K_2P10.1 (TREK-2) channel activator
Chemical Name:	4,4'-[[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis[benzenamine]
Purity:	≥99% (HPLC)
Molecular Weight:	518.45

View Full Technical Details for GI 530159

Technical Data
Citations

Biological Activity for GI 530159

GI 530159 is a TREK1 and TREK2 channel activator (EC₅₀ = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro.

Compound Libraries for GI 530159

GI 530159 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GI 530159

M. Wt	518.45
Formula	C₂₇H₂₀F₆N₂O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	69563-88-8
PubChem ID	94652
InChi Key	HHLMWQDRYZAENA-UHFFFAOYSA-N
Smiles	NC1=CC=C(C=C1)OC2=CC=C(C(C(F)(F)F)(C(F)(F)F)C3=CC=C(C=C3)OC4=CC=C(C=C4)N)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GI 530159

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.84	100
	ethanol	25.92	50

Preparing Stock Solutions for GI 530159

The following data is based on the product molecular weight 518.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.93 mL	9.64 mL	19.29 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
10 mM	0.19 mL	0.96 mL	1.93 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for GI 530159

References are publications that support the biological activity of the product.

Loucif GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K_2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br.J.Pharmacol. 2018 PMID: 29150838