GLPG 0187

Name: GLPG 0187
Brand: Tocris Bioscience
SKU: 7059

Tocris Bioscience, part of Bio-Techne | Catalog # 7059

Citations (1)

COA / SDS

Potent αv integrin inhibitor

Key Product Details

Description:	Potent αv integrin inhibitor
Chemical Name:	3-[[2,5-Dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
Purity:	≥97% (HPLC)
Molecular Weight:	595.71

View Full Technical Details for GLPG 0187

Technical Data
Citations

Biological Activity for GLPG 0187

GLPG 0187 is a potent αv integrin inhibitor (IC₅₀ values are 1.2-3.7 nM). Inhibits osteoclastic bone resorption and angiogenesis in vitro and in vivo. Suppresses epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells, without inhibiting cell growth. Induces detachment and necrosis of GL-261 and SMA-560 murine glioma cells.

Technical Data for GLPG 0187

M. Wt	595.71
Formula	C₂₉H₃₇N₇O₅S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1320346-97-1
PubChem ID	53340771
InChi Key	CXHCNOMGODVIKB-VWLOTQADSA-N
Smiles	O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC=C(OC)C=C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GLPG 0187

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.96	10

Preparing Stock Solutions for GLPG 0187

The following data is based on the product molecular weight 595.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.79 mL	83.93 mL	167.87 mL
0.5 mM	3.36 mL	16.79 mL	33.57 mL
1 mM	1.68 mL	8.39 mL	16.79 mL
5 mM	0.34 mL	1.68 mL	3.36 mL

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References for GLPG 0187

References are publications that support the biological activity of the product.

Silginer Integrin inhibition promotes atypical anoikis in glioma cells. Cell Death Dis. 2014 PMID: 24457956
van der Horst, Targeting of αv-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia 2011 PMID: 21677875