Glycine

Name: Glycine
Brand: Tocris Bioscience
SKU: 0219
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0219

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Citations (376)

COA / SDS

Endogenous potentiator of NMDA receptors

Key Product Details

Description:	Endogenous potentiator of NMDA receptors
Chemical Name:	Aminoethanoic acid
Molecular Weight:	75.07

View Full Technical Details for Glycine

Technical Data
Citations / Reviews (1)

Biological Activity for Glycine

One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors.

Technical Data for Glycine

M. Wt	75.07
Formula	C₂H₅NO₂
Storage	Store at RT
CAS Number	56-40-6
PubChem ID	750
InChi Key	DHMQDGOQFOQNFH-UHFFFAOYSA-N
Smiles	NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Glycine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for Glycine

The following data is based on the product molecular weight 75.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	13.32 mL	66.60 mL	133.21 mL
5 mM	2.66 mL	13.32 mL	26.64 mL
10 mM	1.33 mL	6.66 mL	13.32 mL
50 mM	0.27 mL	1.33 mL	2.66 mL

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Reconstitution Calculator

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References for Glycine

References are publications that support the biological activity of the product.

Johnson and Ascher Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature
Kuhse The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr.Opin.Neurobiol. 1995 PMID: 7850154
Ascher and Johnson The NMDA receptor, its channel and its modulation by glycine. The NMDA Receptor (2nd edition). Eds. G.L.Collingr
Betz Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci. 1991 PMID: 1722365