GLYX 13

Name: GLYX 13
Brand: Tocris Bioscience
SKU: 3406

Tocris Bioscience, part of Bio-Techne | Catalog # 3406

Citations (8)

COA / SDS

NMDA partial agonist; acts at the glycine site

Key Product Details

Purity:	≥95%
Molecular Weight:	413.47 kDa

View Full Technical Details for GLYX 13

Technical Data
Citations

Biological Activity for GLYX 13

GLYX 13 is a NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Also promotes VGF and BDNF release and increases ERK/mTOR signaling. Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant.

Technical Data for GLYX 13

M. Wt	413.47 kDa
Formula	C₁₈H₃₁N₅O₆
Storage	Store at -20°C
Purity	≥95%
CAS Number	117928-94-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GLYX 13

Solubility

Soluble Soluble to 2 mg/ml in water

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References for GLYX 13

References are publications that support the biological activity of the product.

Moskal et al. GLYX-13: A monoclonal antibody-derived peptide that acts as an N-MthD.-aspartate receptor modulator. Neuropharmacology, 2005;49:1077 PMID: 16051282
Wood et al. Antinociceptive action of GLYX-13: a N-MthD.-aspartate receptor glycine site partial agonist. Neuroreport., 2008;19:1059 PMID: 18580579
Burgdorf et al. The N-MthD.-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiol.Aging, 2009;32:698 PMID: 19446371