GM 6001

Name: GM 6001
Brand: Tocris Bioscience
SKU: 2983

Tocris Bioscience, part of Bio-Techne | Catalog # 2983

Citations (83)

COA / SDS

Broad spectrum MMP inhibitor

Key Product Details

Description:	Broad spectrum MMP inhibitor
Alternative Names:	Galardin,Ilomastat
Chemical Name:	(2R)-N⁴-Hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
Purity:	≥95% (HPLC)
Molecular Weight:	388.46

View Full Technical Details for GM 6001

Technical Data
Citations

Biological Activity for GM 6001

GM 6001 is a broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (K_i = 0.4 nM).

Technical Data for GM 6001

M. Wt	388.46
Formula	C₂₀H₂₈N₄O₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	142880-36-2
PubChem ID	132519
InChi Key	NITYDPDXAAFEIT-DYVFJYSZSA-N
Smiles	O=C(NC)[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)CC2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GM 6001

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.85	100

Preparing Stock Solutions for GM 6001

The following data is based on the product molecular weight 388.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.87 mL	25.74 mL
5 mM	0.51 mL	2.57 mL	5.15 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for GM 6001

References are publications that support the biological activity of the product.

Grobelny Inhibition of skin fibroblast Col., thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 1992 PMID: 1322694
Chao Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 2007 PMID: 17678888
Shichi Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 2011 PMID: 21602423