GNF 5837

Name: GNF 5837
Brand: Tocris Bioscience
SKU: 4559

Tocris Bioscience, part of Bio-Techne | Catalog # 4559

Citations (9)

COA / SDS

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

Key Product Details

Description:	Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC
Chemical Name:	N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Purity:	≥98% (HPLC)
Molecular Weight:	535.49

View Full Technical Details for GNF 5837

Technical Data
Citations

Biological Activity for GNF 5837

GNF 5837 is a potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC₅₀ values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC₅₀ values are 0.87 and 0.91 μM respectively). Orally bioavailable.

Compound Libraries for GNF 5837

GNF 5837 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GNF 5837

M. Wt	535.49
Formula	C₂₈H₂₁F₄N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1033769-28-6
PubChem ID	59397065
InChi Key	YYDUWLSETXNJJT-MTJSOVHGSA-N
Smiles	O=C2NC1=CC(NC4=C(C)C=CC(NC(NC5=C(F)C=CC(C(F)(F)F)=C5)=O)=C4)=CC=C1/C2=C/C3=CC=CN3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GNF 5837

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	53.55	100
	ethanol	5.35	10

Preparing Stock Solutions for GNF 5837

The following data is based on the product molecular weight 535.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.34 mL	18.67 mL
5 mM	0.37 mL	1.87 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for GNF 5837

References are publications that support the biological activity of the product.

Albaugh Discovery of GNF-5837, a selective TRK inhibitor with efficacy in rodent cancer tumor models. ACS Med.Chem.Lett. 2012 PMID: 24900443