Go 6983

Name: Go 6983
Brand: Tocris Bioscience
SKU: 2285
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2285

(2)

Citations (133)

COA / SDS

Broad spectrum PKC inhibitor

Key Product Details

Description:	Broad spectrum PKC inhibitor
Alternative Names:	Goe 6983
Chemical Name:	3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Purity:	≥98% (HPLC)
Molecular Weight:	442.51

View Full Technical Details for Go 6983

Technical Data
Citations / Reviews (2)

Biological Activity for Go 6983

Go 6983 is a broad spectrum protein kinase C (PKC) inhibitor (IC₅₀ values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).

Technical Data for Go 6983

M. Wt	442.51
Formula	C₂₆H₂₆N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	133053-19-7
PubChem ID	3499
InChi Key	LLJJDLHGZUOMQP-UHFFFAOYSA-N
Smiles	O=C(N1)C(C2=CNC3=C2C=CC=C3)=C(C4=CN(CCCN(C)C)C5=C4C=C(OC)C=C5)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Go 6983

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.12	50

Preparing Stock Solutions for Go 6983

The following data is based on the product molecular weight 442.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.52 mL	22.60 mL	45.20 mL
2.5 mM	0.90 mL	4.52 mL	9.04 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

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References for Go 6983

References are publications that support the biological activity of the product.

Gafni Derivation of novel human ground state naive pluripotent stem cells. Nature 2013 PMID: 24172903
Peterman Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion. J.Cardiovasc.Pharmacol. 2004 PMID: 15071351
Young Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Drug Rev. 2005 PMID: 16252018
Gschwendt Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes. FEBS Lett. 1996 PMID: 8772178