GoSlo SR 5-69

Name: GoSlo SR 5-69
Brand: Tocris Bioscience
SKU: 5814

Tocris Bioscience, part of Bio-Techne | Catalog # 5814

COA / SDS

KCa1.1 (BK) channel activator

Key Product Details

Description:	K_Ca1.1 (BK) channel activator
Chemical Name:	Sodium 1-Amino-9,10-dioxo-4-((5,6,7,8-tetrahydronaphthalen-2-yl)amino)-9,10-dihydroanthracene-2-sulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	470.47

View Full Technical Details for GoSlo SR 5-69

Technical Data
Citations

Biological Activity for GoSlo SR 5-69

GoSlo SR 5-69 is a BK channel activator (EC₅₀ = 251 nM). Shifts the voltage required for half maximal negatively (DV_1/2 = -104 mV).

Technical Data for GoSlo SR 5-69

M. Wt	470.47
Formula	C₂₄H₁₉N₂NaO₅S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1363419-31-1
PubChem ID	56944133
InChi Key	JOJJZTFRBZWSBX-UHFFFAOYSA-M
Smiles	NC1=C2C(C3=CC=CC=C3C(C2=C(C=C1S(=O)([O-])=O)NC4=CC=C5CCCCC5=C4)=O)=O.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GoSlo SR 5-69

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.05	100

Preparing Stock Solutions for GoSlo SR 5-69

The following data is based on the product molecular weight 470.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.63 mL	21.26 mL
5 mM	0.43 mL	2.13 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for GoSlo SR 5-69

References are publications that support the biological activity of the product.

Schewe A pharmacological master key mechanism that unlocks the selectivity filter gate in K⁺ channels. Science 2019 PMID: 30792303
Roy Development of GoSlo-SR-5-69, a potent activator of large conductance Ca²⁺-activated K⁺ (BK) channels. Eur.J.Med.Chem. 2014 PMID: 24561672