GRI 977143

Name: GRI 977143
Brand: Tocris Bioscience
SKU: 4779

Tocris Bioscience, part of Bio-Techne | Catalog # 4779

Citations (2)

COA / SDS

Selective LPA2 receptor non-lipid agonist

Key Product Details

Description:	Selective LPA₂ receptor non-lipid agonist
Chemical Name:	2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	391.44

View Full Technical Details for GRI 977143

Technical Data
Citations

Biological Activity for GRI 977143

GRI 977143 is a selective lysophosphatidic acid 2 (LPA₂) receptor non-lipid agonist (EC₅₀ = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.

Technical Data for GRI 977143

M. Wt	391.44
Formula	C₂₂H₁₇NO₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	325850-81-5
PubChem ID	3114900
InChi Key	GMVZUCHUOYUMLL-UHFFFAOYSA-N
Smiles	O=C(C2=CC=CC3=CC=CC(C4=O)=C23)N4CCCSC1=CC=CC=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GRI 977143

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.14	100

Preparing Stock Solutions for GRI 977143

The following data is based on the product molecular weight 391.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.77 mL	25.55 mL
5 mM	0.51 mL	2.55 mL	5.11 mL
10 mM	0.26 mL	1.28 mL	2.55 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for GRI 977143

References are publications that support the biological activity of the product.

Kiss Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochim.Biophys.Acta 2013 PMID: 23127512
Kiss Virtual screening for LPA₂-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol.Pharmacol. 2012 PMID: 22968304