Grifolic acid

Name: Grifolic acid
Brand: Tocris Bioscience
SKU: 4581

Tocris Bioscience, part of Bio-Techne | Catalog # 4581

Citations (2)

COA / SDS

Selective partial FFA4 (GPR120) agonist

Key Product Details

Description:	Selective partial FFA4 (GPR120) agonist
Chemical Name:	2,4-Dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	372.5

View Full Technical Details for Grifolic acid

Technical Data
Citations

Biological Activity for Grifolic acid

Grifolic acid is a selective partial FFA4 (GPR120) agonist. Induces ERK and [Ca²⁺]_i responses in cells expressing GPR120, but not those expressing GPR40.

Technical Data for Grifolic acid

M. Wt	372.5
Formula	C₂₃H₃₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	80557-12-6
PubChem ID	9976563
InChi Key	QPIZDZGIXDKCRC-JTCWOHKRSA-N
Smiles	OC1=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)C(O)=C(C(O)=O)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Grifolic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.25	100

Preparing Stock Solutions for Grifolic acid

The following data is based on the product molecular weight 372.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.42 mL	26.85 mL
5 mM	0.54 mL	2.68 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for Grifolic acid

References are publications that support the biological activity of the product.

Sun Structure-activity relationships of GPR120 agonists based on a docking simulation. Mol.Pharmacol. 2010 PMID: 20685848
Hara Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 2009 PMID: 19471906