GS 6201

Tocris Bioscience, part of Bio-Techne | Catalog # 4727

COA / SDS

Selective A2B antagonist

Key Product Details

Chemical Name:	3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione
Purity:	≥99%

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Technical Data
Citations

Biological Activity for GS 6201

GS 6201 is a selective antagonist of adenosine A_2B receptors (K_i values are 22, 1070, 1940 and 3280 nM for human A_2B, A₃, A₁ and A_2A receptors respectively). Attenuates allergen-, NECA- and AMP-induced airway reactivity in an allergic mouse model of asthma. Also shown to attenuate the inflammatory response during acute myocardial infarction in mice; reduces caspase-1 activity in the heart.

Technical Data for GS 6201

Formula	C₂₁H₂₁F₃N₆O₂
Storage	Store at -20°C
Purity	≥99%
CAS Number	752222-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GS 6201

Solubility

Soluble Soluble to 5 mM in DMSO

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References for GS 6201

References are publications that support the biological activity of the product.

Elzein et al. Discovery of a novel A_2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases. J.Med.Chem., 2008;51:2267 PMID: 18321039
Toldo et al. GS-6201, a selective blocker of the A_2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J.Pharmacol.Exp.Ther., 2012;343:587 PMID: 22923737
Mustafa et al. Effect of a specific and selective A_2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma. J.Pharmacol.Exp.Ther., 2007;320:1246 PMID: 17159162

GS 6201

Tocris Bioscience, part of Bio-Techne | Catalog # 4727

Key Product Details

Biological Activity for GS 6201

Technical Data for GS 6201

Solubility for GS 6201

Dilution Calculator

Reconstitution Calculator

References for GS 6201

Product Documents for GS 6201

COA

Certificate of Analysis

SDS

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