GSK 143

Name: GSK 143
Brand: Tocris Bioscience
SKU: 6362

Tocris Bioscience, part of Bio-Techne | Catalog # 6362

Citations (2)

COA / SDS

Syk inhibitor

Key Product Details

Description:	Syk inhibitor
Chemical Name:	2-[[(3R,4R)-3-Aminotetrahydro-2H-pyran-4-yl]amino]-4-[(4-methylphenyl)amino]-5-pyrimidinecarboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	415.32

View Full Technical Details for GSK 143

Technical Data
Citations

Biological Activity for GSK 143

GSK 143 is a spleen tyrosine kinase (Syk) inhibitor (pIC₅₀ = 7.5). Also inhibits phosphorylated Erk (pIC₅₀ = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines.

Compound Libraries for GSK 143

GSK 143 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 143

M. Wt	415.32
Formula	C₁₇H₂₂N₆O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2341796-81-2
PubChem ID	46865656
InChi Key	InChIKey=UEHPBSLIDBDMCZ-WICJZZOFSA-N
Smiles	CC1=CC=C(C=C1)NC2=NC(N[C@@H]3CCOC[C@@H]3N)=NC=C2C(N)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 143

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	41.53	100
	DMSO	41.53	100

Preparing Stock Solutions for GSK 143

The following data is based on the product molecular weight 415.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.04 mL	24.08 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.20 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Molarity Calculator

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Reconstitution Calculator

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References for GSK 143

References are publications that support the biological activity of the product.

Varghese Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 2018 PMID: 28770560
Liddle Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 2011 PMID: 21903390