GSK 2250665A

Name: GSK 2250665A
Brand: Tocris Bioscience
SKU: 5401

Tocris Bioscience, part of Bio-Techne | Catalog # 5401

COA / SDS

Itk inhibitor

Key Product Details

Description:	Itk inhibitor
Chemical Name:	trans-4-[[4-[(6-Ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]cyclohexanol
Purity:	≥97% (HPLC)
Molecular Weight:	459.61

View Full Technical Details for GSK 2250665A

Technical Data
Citations

Biological Activity for GSK 2250665A

GSK 2250665A is an Itk inhibitor (pK_i = 9.2). Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC₅₀ values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for GSK 2250665A

GSK 2250665A is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 2250665A

M. Wt	459.61
Formula	C₂₆H₂₉N₅OS
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	1246030-96-5
PubChem ID	73352604
InChi Key	DPRNXTSMYVCYLJ-XUTJKUGGNA-N
Smiles	CCC1=CC=C(N=C(NC3=NC(N[C@H]5CC[C@H](O)CC5)=NC(CC4=CC=CC=C4)=C3)S2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 2250665A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.96	100
	1eq. HCl	9.19	20

Preparing Stock Solutions for GSK 2250665A

The following data is based on the product molecular weight 459.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.88 mL	21.76 mL
5 mM	0.44 mL	2.18 mL	4.35 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for GSK 2250665A

References are publications that support the biological activity of the product.

Alder Identification of a novel and selective series of Itk inhibitors via a template-hopping strategy. ACS Med.Chem.Lett. 2013 PMID: 24900590