GSK 329

Name: GSK 329
Brand: Tocris Bioscience
SKU: 7637

Tocris Bioscience, part of Bio-Techne | Catalog # 7637

COA / SDS

Potent and selective TNNI3K inhibitor, orally bioavailable

Key Product Details

Description:	Potent and selective TNNI3K inhibitor, orally bioavailable
Chemical Name:	N-[3,5-Dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]urea
Purity:	≥98% (HPLC)
Molecular Weight:	472.25

View Full Technical Details for GSK 329

Technical Data
Citations

Biological Activity for GSK 329

GSK 329 is a potent and selective TNNI3K (cardiac troponin I-interacting kinase) inhibitor (IC₅₀ = 10 nM). It exhibits selectivity for TNNI3K over human VEGFR2 (40-fold), p38α (80-fold), B-Raf (>200-fold) and displays >100-fold selectivity over 80% of 185 kinases tested. In vivo, GSK 329 reduces infarct size, ROS levels, and p38 activation in a mouse model of ischemia/reperfusion cardiac injury. This compound is orally bioavailable.

Technical Data for GSK 329

M. Wt	472.25
Formula	C₁₉H₁₄Cl₂F₃N₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1268490-12-5
PubChem ID	50997674
InChi Key	QOQADIYOLOHRAW-UHFFFAOYSA-N
Smiles	CNC1=CC(OC2=C(C=C(C=C2Cl)NC(NC3=CC(C(F)(F)F)=CC=C3)=O)Cl)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 329

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.23	100
	ethanol	9.45	20

Preparing Stock Solutions for GSK 329

The following data is based on the product molecular weight 472.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.59 mL	21.18 mL
5 mM	0.42 mL	2.12 mL	4.24 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for GSK 329

References are publications that support the biological activity of the product.

Vagnozzi Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart. Sci.Transl.Med. 2013 PMID: 24132636
Patterson Identification of diarylurea inhibitors of the cardiac-specific kinase TNNI3K by designing selectivity against VEGFR2, p38a, and B-Raf. J.Med.Chem. 2021 PMID: 34699203