GSK 9027

Name: GSK 9027
Brand: Tocris Bioscience
SKU: 4116

Tocris Bioscience, part of Bio-Techne | Catalog # 4116

Citations (3)

COA / SDS

Glucocorticoid receptor agonist

Key Product Details

Description:	Glucocorticoid receptor agonist
Chemical Name:	N-[4-[1-(4-Fluorophenyl)-1H-indazol-5-yl-3-(trifluoromethyl)phenyl]benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	525.52

View Full Technical Details for GSK 9027

Technical Data
Citations

Biological Activity for GSK 9027

GSK 9027 is a glucocorticoid receptor agonist (pIC₅₀ = 8). Inhibits production of the proinflammatory mediator IL-6 in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data for GSK 9027

M. Wt	525.52
Formula	C₂₇H₁₉F₄N₃O₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1229096-88-1
PubChem ID	24882669
InChi Key	DXBJGDVBQPEMOB-UHFFFAOYSA-N
Smiles	FC(C=C3)=CC=C3N2C1=CC=C(C4=C(C(F)(F)F)C=C(NS(CC5=CC=CC=C5)(=O)=O)C=C4)C=C1C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 9027

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.55	100

Preparing Stock Solutions for GSK 9027

The following data is based on the product molecular weight 525.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.51 mL	19.03 mL
5 mM	0.38 mL	1.90 mL	3.81 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for GSK 9027

References are publications that support the biological activity of the product.

Yates Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists. J.Med.Chem. 2010 PMID: 20469868