GT 949

Name: GT 949
Brand: Tocris Bioscience
SKU: 6578

Tocris Bioscience, part of Bio-Techne | Catalog # 6578

Citations (3)

COA / SDS

Potent and selective positive allosteric modulator of EAAT2

Key Product Details

Description:	Potent and selective positive allosteric modulator of EAAT2
Chemical Name:	3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	527.66

View Full Technical Details for GT 949

Technical Data
Citations

Biological Activity for GT 949

GT 949 is a potent and selective EAAT2 positive allosteric modulator (EC₅₀ = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Enhances glutamate uptake by cultured astrocytes by approximately 58%. Exhibits no significant effect on DAT, SERT and NET or NMDA receptors. Neuroprotective in an in vitro model of excitotoxicity.

Compound Libraries for GT 949

GT 949 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GT 949

M. Wt	527.66
Formula	C₃₀H₃₇N₇O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	460330-27-2
PubChem ID	3195790
InChi Key	ZVWPOIUAPXDLMB-UHFFFAOYSA-N
Smiles	COC1=CC=C2NC(C(C(C3=NN=NN3CCC4=CC=CC=C4)N5CCN(C6CCCCC6)CC5)=CC2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GT 949

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.77	100

Preparing Stock Solutions for GT 949

The following data is based on the product molecular weight 527.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.48 mL	18.95 mL
5 mM	0.38 mL	1.90 mL	3.79 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for GT 949

References are publications that support the biological activity of the product.

Falcucci Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model. ACS Chem.Neurosci. 2019 PMID: 31257852
Kortagere Identification of novel allosteric modulators of glutamate transporter EAAT2. ACS Chem.Neurosci. 2018 PMID: 29140675