Guanfacine hydrochloride

Name: Guanfacine hydrochloride
Brand: Tocris Bioscience
SKU: 1030

Tocris Bioscience, part of Bio-Techne | Catalog # 1030

Citations (11)

COA / SDS

α2A agonist

Key Product Details

Description:	α_2A agonist
Chemical Name:	[(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	282.56

View Full Technical Details for Guanfacine hydrochloride

Technical Data
Citations

Biological Activity for Guanfacine hydrochloride

Guanfacine hydrochloride is a selective α_2A-adrenoceptor agonist (K_d = 31 nM). Displays 60-fold selectivity over α_2B-adrenoceptors.

Technical Data for Guanfacine hydrochloride

M. Wt	282.56
Formula	C₉H₉Cl₂N₃O.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	29110-48-3
PubChem ID	71401
InChi Key	DGFYECXYGUIODH-UHFFFAOYSA-N
Smiles	Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Guanfacine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	28.26	100
	DMSO	28.26	100

Preparing Stock Solutions for Guanfacine hydrochloride

The following data is based on the product molecular weight 282.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.54 mL	17.70 mL	35.39 mL
5 mM	0.71 mL	3.54 mL	7.08 mL
10 mM	0.35 mL	1.77 mL	3.54 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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Reconstitution Calculator

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References for Guanfacine hydrochloride

References are publications that support the biological activity of the product.

Uhlen and Wikberg Delineation of rat kidney α_2A- and α_2B-adrenoceptors with [³H]RX821002 radioligand binding: computer modelling reveals that guanf. is an α_2A -selective compound. Eur.J.Pharmacol. 1991 PMID: 1666366
Intengan and Smyth Alpha-2a/d adrenoceptor subtype stimulation by guanf. increases osmolar clearance. J.Pharmacol.Exp.Ther. 1997 PMID: 9103479