GW 0742

Name: GW 0742
Brand: Tocris Bioscience
SKU: 2229

Tocris Bioscience, part of Bio-Techne | Catalog # 2229

Citations (45)

COA / SDS

Highly selective, potent PPARδ agonist

Key Product Details

Description:	Highly selective, potent PPARδ agonist
Chemical Name:	[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	471.49

View Full Technical Details for GW 0742

Technical Data
Citations

Biological Activity for GW 0742

GW 0742 is a potent and highly selective PPARδ agonist. EC₅₀ values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for GW 0742

GW 0742 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GW 0742

M. Wt	471.49
Formula	C₂₁H₁₇F₄NO₃S₂
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	317318-84-6
PubChem ID	9934458
InChi Key	HWVNEWGKWRGSRK-UHFFFAOYSA-N
Smiles	CC1=C(CSC2=CC(C)=C(OCC(O)=O)C=C2)SC(=N1)C1=CC(F)=C(C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 0742

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	24.23	50
	DMSO	48.5	100

Preparing Stock Solutions for GW 0742

The following data is based on the product molecular weight 471.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.60 mL	21.21 mL
5 mM	0.42 mL	2.12 mL	4.24 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for GW 0742

References are publications that support the biological activity of the product.

Smith Effect of the peroxisome proliferator-activated receptor β activator GW0742 in rat cultured cerebellar granule neurons. J.Neurosci.Res. 2004 PMID: 15211590
Yue In vivo activation of peroxisome proliferator-activayed receptor-δ protects the heart from ischemia/reperfusion injury in Zucker fatty rats. J.Pharm.Exp.Ther.
Sznaidman Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity. Bioorg.Med.Chem.Lett. 2003 PMID: 12699745