GW 542573X

Name: GW 542573X
Brand: Tocris Bioscience
SKU: 4311
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4311

(1)

Citations (1)

COA / SDS

Selective KCa2.1 (SK) channel activator

Key Product Details

Chemical Name:	4-[[[[(2-Methoxyphenyl)amino]carbonyl]oxy]methyl]-piperidinecarboxylic acid-1,1-dimethylethyl ester
Purity:	≥99%
Molecular Weight:	364.44 kDa

View Full Technical Details for GW 542573X

Technical Data
Citations / Reviews (1)

Biological Activity for GW 542573X

GW 542573X is an activator of small-conductance Ca²⁺-activated K⁺ channels (K_Ca2); selective for K_Ca2.1 (EC₅₀ = 8.2 μM in HEK293 cells expressing hK_Ca2.1) with the profile hK_Ca2.1 > hK_Ca2.2 = hK_Ca2.3 > hK_Ca3.1 (IK).

Technical Data for GW 542573X

M. Wt	364.44 kDa
Formula	C₁₉H₂₈N₂O₅
Storage	Store at +4°C
Purity	≥99%
CAS Number	660846-41-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 542573X

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for GW 542573X

References are publications that support the biological activity of the product.

Hougaard et al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methyoxy-phenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 298 in Mol.Pharmacol., 2009;76:569 PMID: 19515965