GW 803430

Name: GW 803430
Brand: Tocris Bioscience
SKU: 4242

Tocris Bioscience, part of Bio-Techne | Catalog # 4242

Citations (1)

COA / SDS

MCH1 antagonist

Key Product Details

Description:	MCH₁ antagonist
Chemical Name:	6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one
Purity:	≥95% (HPLC)
Molecular Weight:	481.99

View Full Technical Details for GW 803430

Technical Data
Citations

Biological Activity for GW 803430

GW 803430 is a selective melanin-concentrating hormone receptor 1 (MCH₁) antagonist (IC₅₀ = 9.3 nM). Displays antiobesity and antidepressant-like effects in rats and mice. Orally active.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data for GW 803430

M. Wt	481.99
Formula	C₂₅H₂₄ClN₃O₃S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	515141-51-2
PubChem ID	9826520
InChi Key	MWULMTACIBZPGN-UHFFFAOYSA-N
Smiles	ClC(C=C3)=CC=C3C(S2)=CC1=C2C(N(C4=CC(OC)=C(OCCN5CCCC5)C=C4)C=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 803430

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. HCl	14.75	25

Preparing Stock Solutions for GW 803430

The following data is based on the product molecular weight 481.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.30 mL	41.49 mL	82.99 mL
1.25 mM	1.66 mL	8.30 mL	16.60 mL
2.5 mM	0.83 mL	4.15 mL	8.30 mL
12.5 mM	0.17 mL	0.83 mL	1.66 mL

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References for GW 803430

References are publications that support the biological activity of the product.

Gehlert Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J.Pharmacol.Exp.Ther. 2009 PMID: 19182070
Rivera Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity. Curr.Med.Chem. 2008 PMID: 18393860