GW 843682X

Name: GW 843682X
Brand: Tocris Bioscience
SKU: 2977

Tocris Bioscience, part of Bio-Techne | Catalog # 2977

Citations (21)

COA / SDS

Selective inhibitor of PLK1 and PLK3

Key Product Details

Description:	Selective inhibitor of PLK1 and PLK3
Chemical Name:	5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	477.46

View Full Technical Details for GW 843682X

Technical Data
Citations

Biological Activity for GW 843682X

GW 843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC₅₀ values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for GW 843682X

GW 843682X is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for GW 843682X

M. Wt	477.46
Formula	C₂₂H₁₈F₃N₃O₄S
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	660868-91-7
PubChem ID	9826308
InChi Key	JSKUWFIZUALZLX-UHFFFAOYSA-N
Smiles	O=C(N)C(S3)=C(OCC4=CC=CC=C4C(F)(F)F)C=C3N2C1=CC(OC)=C(OC)C=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 843682X

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.81	75
	ethanol	2.39	5

Preparing Stock Solutions for GW 843682X

The following data is based on the product molecular weight 477.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	2.79 mL	13.96 mL	27.93 mL
3.75 mM	0.56 mL	2.79 mL	5.59 mL
7.5 mM	0.28 mL	1.40 mL	2.79 mL
37.5 mM	0.06 mL	0.28 mL	0.56 mL

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References for GW 843682X

References are publications that support the biological activity of the product.

Lansing In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol.Cancer Ther. 2007 PMID: 17267659