H2L5186303

Name: H2L5186303
Brand: Tocris Bioscience
SKU: 4878
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4878

(1)

Citations (10)

COA / SDS

Potent and selective LPA2 receptor antagonist

Key Product Details

Description:	Potent and selective LPA₂ receptor antagonist
Chemical Name:	(Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	488.45

View Full Technical Details for H2L5186303

Technical Data
Citations / Reviews (1)

Biological Activity for H2L5186303

H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA₂) receptor antagonist (IC₅₀ values are 8.9, 1230 and 27354 nM for LPA₂, LPA₃ and LPA₁ receptors respectively, in a LPA-elicited calcium mobilization assay).

Technical Data for H2L5186303

M. Wt	488.45
Formula	C₂₆H₂₀N₂O₈
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	139262-76-3
PubChem ID	90488981
InChi Key	HZFPOTBCYPWQSH-DZDAAMPGSA-N
Smiles	O=C(/C=C\C(O)=O)NC(C=C3)=CC=C3OC1=CC(OC2=CC=C(NC(/C=C\C(O)=O)=O)C=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for H2L5186303

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.84	100

Preparing Stock Solutions for H2L5186303

The following data is based on the product molecular weight 488.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.24 mL	20.47 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.20 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for H2L5186303

References are publications that support the biological activity of the product.

Fells Structure-based drug design identifies novel LPA₃ antagonists. Bioorg.Med.Chem. 2009 PMID: 19800804
Fells Identification of non-lipid LPA₃ antagonists by virtual screening. Bioorg.Med.Chem. 2008 PMID: 18467108