HC 067047

Name: HC 067047
Brand: Tocris Bioscience
SKU: 4100
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4100

(2)

Citations (89)

COA / SDS

Potent and selective TRPV4 antagonist

Key Product Details

Description:	Potent and selective TRPV4 antagonist
Chemical Name:	2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	471.51

View Full Technical Details for HC 067047

Technical Data
Citations / Reviews (2)

Biological Activity for HC 067047

HC 067047 is a potent and selective TRPV4 antagonist. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC₅₀ values are 17, 48 and 133 nM respectively). Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC₅₀ = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.

Technical Data for HC 067047

M. Wt	471.51
Formula	C₂₆H₂₈F₃N₃O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	883031-03-6
PubChem ID	2742550
InChi Key	NCZYSQOTAYFTNM-UHFFFAOYSA-N
Smiles	CC1=C(C(NC4=CC(C(F)(F)F)=CC=C4)=O)C=C(C3=CC=CC=C3)N1CCCN2CCOCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HC 067047

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.15	100
	ethanol	11.79	25

Preparing Stock Solutions for HC 067047

The following data is based on the product molecular weight 471.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.60 mL	21.21 mL
5 mM	0.42 mL	2.12 mL	4.24 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for HC 067047

References are publications that support the biological activity of the product.

Everaerts Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc.Natl.Acad.Sci.