HEAT hydrochloride

Name: HEAT hydrochloride
Brand: Tocris Bioscience
SKU: 0535

Tocris Bioscience, part of Bio-Techne | Catalog # 0535

Citations (5)

COA / SDS

Highly selective α1 antagonist

Key Product Details

Description:	Highly selective α₁ antagonist
Alternative Names:	BE 2254
Chemical Name:	2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	331.84

View Full Technical Details for HEAT hydrochloride

Technical Data
Citations

Biological Activity for HEAT hydrochloride

HEAT hydrochloride is a very selective α₁-adrenoceptor antagonist, precursor of the 3-[¹²⁵I]-derivative.

Technical Data for HEAT hydrochloride

M. Wt	331.84
Formula	C₁₉H₂₁NO₂.HCl
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	30007-39-7
PubChem ID	34771
InChi Key	VCZXZECZIRGUCZ-UHFFFAOYSA-N
Smiles	Cl.OC1=CC=C(CCNCC2CCC3=CC=CC=C3C2=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HEAT hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.18	100

Preparing Stock Solutions for HEAT hydrochloride

The following data is based on the product molecular weight 331.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.14 mL
5 mM	0.60 mL	3.01 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for HEAT hydrochloride

References are publications that support the biological activity of the product.

Williams Interaction of 2-[β-(4-hydroxyphenyl)ethylaminomethyl]tetralone (BE 2254: 'HEAT') with catecholamine receptors in rat brain membranes. J.Pharm.Pharmacol. 1978 PMID: 26778
Baumgarten Mechanisms of pressor effect of 5,6-dihydroxytryptamine in pithed rats. Naunyn Schmiedebergs Arch.Pharmacol. 1972 PMID: 4404780