Helianorphin-19

Name: Helianorphin-19
Brand: Tocris Bioscience
SKU: 7541

Tocris Bioscience, part of Bio-Techne | Catalog # 7541

COA / SDS

Potent and selective G protein-biased κ opioid receptor (KOR) agonist

Key Product Details

Description:	Potent and selective G protein-biased κ opioid receptor (KOR) agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1790.21

View Full Technical Details for Helianorphin-19

Technical Data
Citations

Biological Activity for Helianorphin-19

Helianorphin-19 is a high affinity, potent and selective G protein-biased κ-opioid receptor (KOR) agonist (K_i = 25 nM; EC₅₀ = 45 nM). Helianorphin-19 exhibits approximately 200-fold selectivity for KOR over μ and δ-opioid receptors. In vivo Helianorphin-19 shows potent peripheral analgesic efficacy in a mouse model of visceral pain without affecting motor coordination/sedation.

Technical Data for Helianorphin-19

M. Wt	1790.21
Formula	C₈₁H₁₃₂N₂₆O₁₆S₂
Single Letter Sequence	CYGGFLRRCIRPKLK (Modifications: Cyclic peptide, Disulfide bridge: 1-9]
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	WEJHFJXWIBZZTQ-AHUOXLFJSA-N
Smiles	O=C(N[C@@H](CC1=CC=C(C=C1)O)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CCCNC(N)=N)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H]5CCCCN)=O)=O)=O)=O)=O)=O)NC3=O)NC5=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Helianorphin-19

Solubility

Soluble to 2mg/ml in water

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References for Helianorphin-19

References are publications that support the biological activity of the product.

Muratspahić Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal pain. J.Med.Chem. 2021 PMID: 34162205