HIOC

Name: HIOC
Brand: Tocris Bioscience
SKU: 5961

Tocris Bioscience, part of Bio-Techne | Catalog # 5961

Citations (2)

COA / SDS

Selective TrkB receptor agonist; neuroprotectant

Key Product Details

Description:	Selective TrkB receptor agonist; neuroprotectant
Chemical Name:	N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	301.34

View Full Technical Details for HIOC

Technical Data
Citations

Biological Activity for HIOC

HIOC is a selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.

Technical Data for HIOC

M. Wt	301.34
Formula	C₁₆H₁₉N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	314054-36-9
PubChem ID	5012758
InChi Key	ZIMKJLALTRLXJO-UHFFFAOYSA-N
Smiles	OC1=CC=C2NC=C(C2=C1)CCNC(C3CCCNC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HIOC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.13	100

Preparing Stock Solutions for HIOC

The following data is based on the product molecular weight 301.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.32 mL	16.59 mL	33.19 mL
5 mM	0.66 mL	3.32 mL	6.64 mL
10 mM	0.33 mL	1.66 mL	3.32 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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Reconstitution Calculator

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References for HIOC

References are publications that support the biological activity of the product.

Shen N-acetyl serotonin derivatives as potent neuroprotectants for retinas Proc.Natl.Acad.Sci.USA 2012 PMID: 22331903
Setterholm Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC) Tetrahedron Lett. 2015 PMID: 26028783