HJC 0416 hydrochloride

Name: HJC 0416 hydrochloride
Brand: Tocris Bioscience
SKU: 6110

Tocris Bioscience, part of Bio-Techne | Catalog # 6110

COA / SDS

STAT3 inhibitor

Key Product Details

Description:	STAT3 inhibitor
Chemical Name:	2-(3-Aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)benzamide hydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	429.32

View Full Technical Details for HJC 0416 hydrochloride

Technical Data
Citations

Biological Activity for HJC 0416 hydrochloride

HJC 0416 hydrochloride is a STAT3 inhibitor. Downregulates phosphorylation of STAT3 and increases the expression of cleaved caspase-3. Inhibits cell-cycle progression and proliferation in breast and pancreatic cancer cells in vitro (IC₅₀ values are in the range 0.04 - 1.97 μM). Also inhibits growth of ER-negative breast cancer xenografts in mice. Orally bioavailable.

Compound Libraries for HJC 0416 hydrochloride

HJC 0416 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for HJC 0416 hydrochloride

M. Wt	429.32
Formula	C₁₈H₁₇ClN₂O₄S.HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	2415263-08-8
InChi Key	YWFDTXJORDWLGD-UHFFFAOYSA-N
Smiles	ClC(C=C1)=CC(C(NC2=CC=C3C=CS(=O)(C3=C2)=O)=O)=C1OCCCN.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HJC 0416 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.93	100
	water	8.59	20

Preparing Stock Solutions for HJC 0416 hydrochloride

The following data is based on the product molecular weight 429.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.65 mL	23.29 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for HJC 0416 hydrochloride

References are publications that support the biological activity of the product.

Chen Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur.J.Med.Chem. 2014 PMID: 24904966