HOE 140

Tocris Bioscience, part of Bio-Techne | Catalog # 3014

(1)

Citations (42)

COA / SDS

Potent and selective B2 antagonist

Key Product Details

Description:	Potent and selective B₂ antagonist
Alternative Names:	Icatibant
Purity:	≥95% (HPLC)
Molecular Weight:	1304.52

View Full Technical Details for HOE 140

Technical Data
Citations / Reviews (1)

Biological Activity for HOE 140

HOE 140 is a potent and selective bradykinin B₂ receptor antagonist (pA₂ = 9.04). Also inhibits aminopeptidase N (K_i = 9.1 μM).

Technical Data for HOE 140

M. Wt	1304.52
Formula	C₅₉H₈₉N₁₉O₁₃S
Single Letter Sequence	RRPXGXSXXR (Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = D-Tic, X-9 = Oic)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	130308-48-4
PubChem ID	90488794
InChi Key	QURWXBZNHXJZBE-JNFYKTHFSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1C3CCCCC3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HOE 140

Solubility

Soluble to 1mg/ml in water

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References for HOE 140

References are publications that support the biological activity of the product.

Feletou Agonistic and antagonistic properties of the bradykinin B₂ receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 1994 PMID: 8075888
Bawolak The bradykinin B₂ receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B₁ and angiotensin receptors. Eur.J.Pharmacol. 2006 PMID: 17026984
Hock Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 1991 PMID: 1364851