Homoharringtonine

Name: Homoharringtonine
Brand: Tocris Bioscience
SKU: 1416
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1416

(1)

Citations (17)

COA / SDS

Inhibitor of protein synthesis; antileukemic agent

Key Product Details

Description:	Inhibitor of protein synthesis; antileukemic agent
Chemical Name:	Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Purity:	≥98% (HPLC)
Molecular Weight:	545.63

View Full Technical Details for Homoharringtonine

Technical Data
Citations / Reviews (1)

Biological Activity for Homoharringtonine

Homoharringtonine is an inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic. Inhibits SARS-CoV-2 infection in vitro (IC₅₀ = 2.55 μM).

Technical Data for Homoharringtonine

M. Wt	545.63
Formula	C₂₉H₃₉NO₉
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	26833-87-4
PubChem ID	285033
InChi Key	HYFHYPWGAURHIV-JFIAXGOJSA-N
Smiles	O=C([C@](CCCC(O)(C)C)(O)CC(OC)=O)O[C@@H]1C(OC)=C[C@@](N(CCC5)CCC2=CC4=C(OCO4)C=C23)5[C@]31[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Homoharringtonine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for Homoharringtonine

The following data is based on the product molecular weight 545.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.83 mL	9.16 mL	18.33 mL
5 mM	0.37 mL	1.83 mL	3.67 mL
10 mM	0.18 mL	0.92 mL	1.83 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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Reconstitution Calculator

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References for Homoharringtonine

References are publications that support the biological activity of the product.

Choy Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 2020 PMID: 32251767
Fresno Inhibition of translation in eukaryotic systems by harringtonine. Eur.J.Biochem. 1977 PMID: 319998
Zhou Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull.Cancer 1995 PMID: 8745664
Cai Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 2001 PMID: 11368358