HQL 79

Name: HQL 79
Brand: Tocris Bioscience
SKU: 3530

Tocris Bioscience, part of Bio-Techne | Catalog # 3530

Citations (3)

COA / SDS

Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

Key Product Details

Description:	Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
Chemical Name:	4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine
Purity:	≥99% (HPLC)
Molecular Weight:	377.48

View Full Technical Details for HQL 79

Technical Data
Citations

Biological Activity for HQL 79

HQL 79 is an orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC₅₀ = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.

Compound Libraries for HQL 79

HQL 79 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HQL 79

M. Wt	377.48
Formula	C₂₂H₂₇N₅O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	162641-16-9
PubChem ID	6540277
InChi Key	TZQGXAHOROZEKN-UHFFFAOYSA-N
Smiles	C1(CCCN2CCC(OC(C4=CC=CC=C4)C3=CC=CC=C3)CC2)=NN=NN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HQL 79

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.44	25

Preparing Stock Solutions for HQL 79

The following data is based on the product molecular weight 377.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.60 mL	52.98 mL	105.97 mL
1.25 mM	2.12 mL	10.60 mL	21.19 mL
2.5 mM	1.06 mL	5.30 mL	10.60 mL
12.5 mM	0.21 mL	1.06 mL	2.12 mL

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References for HQL 79

References are publications that support the biological activity of the product.

Matsushita Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects. Jpn.J.Pharmacol. 1998 PMID: 9804057
Mohri Prostaglandin D₂-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J.Neurosci. 2006 PMID: 16624958
Aritake Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J.Biol.Chem. 2006 PMID: 16547010