IBMX

Name: IBMX
Brand: Tocris Bioscience
SKU: 2845
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2845

(1)

Citations (127)

COA / SDS

PDE inhibitor (non-selective)

Key Product Details

Description:	PDE inhibitor (non-selective)
Chemical Name:	3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Purity:	≥98% (HPLC)
Molecular Weight:	222.24

View Full Technical Details for IBMX

Technical Data
Citations / Reviews (1)

Biological Activity for IBMX

IBMX is a phosphodiesterase inhibitor (IC₅₀ values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC₅₀ = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.

Compound Libraries for IBMX

IBMX is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for IBMX

M. Wt	222.24
Formula	C₁₀H₁₄N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	28822-58-4
PubChem ID	3758
InChi Key	APIXJSLKIYYUKG-UHFFFAOYSA-N
Smiles	O=C1C2=C(N=CN2)N(CC(C)C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IBMX

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	16.67	75

Preparing Stock Solutions for IBMX

The following data is based on the product molecular weight 222.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	6.00 mL	30.00 mL	60.00 mL
3.75 mM	1.20 mL	6.00 mL	12.00 mL
7.5 mM	0.60 mL	3.00 mL	6.00 mL
37.5 mM	0.12 mL	0.60 mL	1.20 mL

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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References for IBMX

References are publications that support the biological activity of the product.

Lepski cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels. Front.Cell Neurosci. 2013 PMID: 24065885
Freitag Phosphodiesterase inhibitors suppress α₂-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits. Eur.J.Pharmacol. 1998 PMID: 9726632