ICA 110381

Name: ICA 110381
Brand: Tocris Bioscience
SKU: 4950

Tocris Bioscience, part of Bio-Techne | Catalog # 4950

Citations (3)

COA / SDS

KV7.2/7.3 activator; displays anticonvulsant properties

Key Product Details

Description:	K_V7.2/7.3 activator; displays anticonvulsant properties
Chemical Name:	4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	267.11

View Full Technical Details for ICA 110381

Technical Data
Citations

Biological Activity for ICA 110381

ICA 110381 is a K_V7.2/7.3 activator (EC₅₀ = 0.38 μM). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.

Compound Libraries for ICA 110381

ICA 110381 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ICA 110381

M. Wt	267.11
Formula	C₁₂H₈Cl₂N₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	325457-99-6
PubChem ID	4314115
InChi Key	FOYOGIUAMYSVIT-UHFFFAOYSA-N
Smiles	O=C(NC2=CC=C(Cl)N=C2)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ICA 110381

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.71	100
	ethanol	5.34	20

Preparing Stock Solutions for ICA 110381

The following data is based on the product molecular weight 267.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.74 mL	18.72 mL	37.44 mL
5 mM	0.75 mL	3.74 mL	7.49 mL
10 mM	0.37 mL	1.87 mL	3.74 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

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References for ICA 110381

References are publications that support the biological activity of the product.

Boehlen The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br.J.Pharmacol. 2013 PMID: 23176257
Amato N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med.Chem.Lett.