ICI 118,551 hydrochloride

Name: ICI 118,551 hydrochloride
Brand: Tocris Bioscience
SKU: 0821

Tocris Bioscience, part of Bio-Techne | Catalog # 0821

Citations (34)

COA / SDS

Highly selective β2 inverse agonist

Key Product Details

Description:	Highly selective β₂ inverse agonist
Chemical Name:	(±)-erythro-(S,S)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	313.87

View Full Technical Details for ICI 118,551 hydrochloride

Technical Data
Citations

Biological Activity for ICI 118,551 hydrochloride

ICI 118,551 hydrochloride is a very selective β₂ adrenergic inverse agonist (K_i values are 1.2, 120 and 257 nM for β₂, β₁ and β₃ receptors respectively). Active in vivo.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for ICI 118,551 hydrochloride

M. Wt	313.87
Formula	C₁₇H₂₇NO₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	72795-01-8
PubChem ID	46704341
InChi Key	KBXMBGWSOLBOQM-MELYUZJYSA-N
Smiles	CC1=C(CCC2)C2=C(OC[C@@H](O)[C@H](C)NC(C)C)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ICI 118,551 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.14	10
	water	3.14	10

Preparing Stock Solutions for ICI 118,551 hydrochloride

The following data is based on the product molecular weight 313.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.86 mL	159.30 mL	318.60 mL
0.5 mM	6.37 mL	31.86 mL	63.72 mL
1 mM	3.19 mL	15.93 mL	31.86 mL
5 mM	0.64 mL	3.19 mL	6.37 mL

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References for ICI 118,551 hydrochloride

References are publications that support the biological activity of the product.

Bond Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β₂-adrenoceptor. Nature 1995 PMID: 7885448
Ten Berge β₂-but not β₃-adrenoceptors mediate prejunctional inhibition of non-adrenergic non cholinergic contraction of guinea pig main bronchi. Eur.J.Pharmacol. 1995 PMID: 7796855
Cook β-Adrenoceptor subtypes and the opening of plasmalemmal K⁺-channels in trachealis muscle: electrophysiological and mechanical studies in guinea-pig tissue. Br.J.Pharmacol. 1993 PMID: 8104643
Strosberg and Pietri-Rouxel Function and regulation of the β₃-adrenoceptor. TiPS 1996 PMID: 8979772
Bilski The pharmacology of a β2-selective adrenoceptor antagonist (ICI-118,551). J.Cardiovasc.Pharmacol. 1983 PMID: 6191142