ICI 174,864

Name: ICI 174,864
Brand: Tocris Bioscience
SKU: 0820

Tocris Bioscience, part of Bio-Techne | Catalog # 0820

Citations (25)

COA / SDS

δ selective peptide antagonist

Key Product Details

Description:	δ selective peptide antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	691.87

View Full Technical Details for ICI 174,864

Technical Data
Citations

Biological Activity for ICI 174,864

ICI 174,864 is a selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for ICI 174,864

M. Wt	691.87
Formula	C₃₈H₅₃N₅O₇
Single Letter Sequence	YXXFL (Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	89352-67-0
PubChem ID	44149909
InChi Key	XUWLAGNFLUARAN-CHQNGUEUSA-N
Smiles	CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ICI 174,864

Solubility

Soluble to 69.19mg/ml in DMSO and to 1mg/ml in water

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References for ICI 174,864

References are publications that support the biological activity of the product.

Hirning Studies in vitro with ICI-174,864 [D-Pen²,D-Pen⁵]-enkephalin (DPDPE) and [D-Ala²,NMePhe⁴,Gly-ol]-enkephalin (DAGO). Neuropeptides 1985 PMID: 2987739
Cotton ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 1984 PMID: 6323195
Cowan Studies in vivo with ICI-174,864 and [D-Pen²,D-Pen⁵]-enkephalin. Neuropeptides 1985 PMID: 2987731
Cohen Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 1996 PMID: 2875170