ICI 199,441 hydrochloride

Name: ICI 199,441 hydrochloride
Brand: Tocris Bioscience
SKU: 0778

Tocris Bioscience, part of Bio-Techne | Catalog # 0778

Citations (2)

COA / SDS

Potent κ agonist

Key Product Details

Description:	Potent κ agonist
Chemical Name:	2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	427.8

View Full Technical Details for ICI 199,441 hydrochloride

Technical Data
Citations

Biological Activity for ICI 199,441 hydrochloride

ICI 199,441 hydrochloride is a highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for ICI 199,441 hydrochloride

ICI 199,441 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ICI 199,441 hydrochloride

M. Wt	427.8
Formula	C₂₁H₂₄Cl₂N₂O.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	115199-84-3
PubChem ID	3082717
InChi Key	VFLWVWZSDBTGQJ-VEIFNGETSA-N
Smiles	ClC1=C(Cl)C=C(CC(N([C@@]([H])([C@]3=CC=CC=C3)CN2CCCC2)C)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ICI 199,441 hydrochloride

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	50

Preparing Stock Solutions for ICI 199,441 hydrochloride

The following data is based on the product molecular weight 427.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.69 mL	23.38 mL
5 mM	0.47 mL	2.34 mL	4.68 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for ICI 199,441 hydrochloride

References are publications that support the biological activity of the product.

Costello 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 1991 PMID: 1846918
Barlow Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 1991 PMID: 1659636