IEM 1460

Name: IEM 1460
Brand: Tocris Bioscience
SKU: 1636

Tocris Bioscience, part of Bio-Techne | Catalog # 1636

Citations (67)

COA / SDS

Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors

Key Product Details

Description:	Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors
Chemical Name:	N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	454.33

View Full Technical Details for IEM 1460

Technical Data
Citations

Biological Activity for IEM 1460

IEM 1460 is a voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca²⁺-permeable) receptors over GluA2-containing receptors (IC₅₀ values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.

Compound Libraries for IEM 1460

IEM 1460 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for IEM 1460

M. Wt	454.33
Formula	C₁₉H₃₇N₂Br.HBr
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	121034-89-7
PubChem ID	6604954
InChi Key	CQTDZUSQSTUZDA-UHFFFAOYSA-M
Smiles	[Br-].Br.C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C2)C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IEM 1460

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	45.43	100
	DMSO	45.43	100

Preparing Stock Solutions for IEM 1460

The following data is based on the product molecular weight 454.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	11.01 mL	22.01 mL
5 mM	0.44 mL	2.20 mL	4.40 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for IEM 1460

References are publications that support the biological activity of the product.

Schlesinger Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors. Br.J.Pharmacol. 2005 PMID: 15834439
Gittis Selective inhibition of striatal fast-spiking interneurons causes dyskinesias. J.Neurosci. 2012 PMID: 22049415
Buldakova Characterization of AMPA receptor populations in rat brain cells by the use of subunit-specific open channel blocking drug, IEM-1460. Brain Res. 1999 PMID: 10536213