Imatinib mesylate

Name: Imatinib mesylate
Brand: Tocris Bioscience
SKU: 5906

Tocris Bioscience, part of Bio-Techne | Catalog # 5906

Citations (11)

COA / SDS

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Key Product Details

Description:	Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
Alternative Names:	Gleevec,CGP 57148B
Chemical Name:	4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	589.71

View Full Technical Details for Imatinib mesylate

Technical Data
Citations

Biological Activity for Imatinib mesylate

Imatinib mesylate is a potent and selective v-Abl tyrosine kinase inhibitor (IC₅₀ = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC₅₀ values are 9.823 and 17.689 μM, respectively).

Compound Libraries for Imatinib mesylate

Imatinib mesylate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Imatinib is reviewed on the chemical probes website.

Technical Data for Imatinib mesylate

M. Wt	589.71
Formula	C₂₉H₃₁N₇O.CH₄O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	220127-57-1
PubChem ID	123596
InChi Key	YLMAHDNUQAMNNX-UHFFFAOYSA-N
Smiles	CS(O)(=O)=O.CN1CCN(CC1)CC2=CC=C(C(NC3=CC=C(C(NC4=NC=CC(C5=CN=CC=C5)=N4)=C3)C)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Imatinib mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	58.97	100
	DMSO	58.97	100

Preparing Stock Solutions for Imatinib mesylate

The following data is based on the product molecular weight 589.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.70 mL	8.48 mL	16.96 mL
5 mM	0.34 mL	1.70 mL	3.39 mL
10 mM	0.17 mL	0.85 mL	1.70 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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References for Imatinib mesylate

References are publications that support the biological activity of the product.

Juurikivi Inhibition of c-kit tyrosine kinase by ima. mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis. Ann.Rheum.Dis. 2005 PMID: 16014680
Dyall Repurposing of clinically developed drugs for treatment of Middle East Respiratory Syndrome coronavirus infection. Antimicrob.Agents Chemother. 2014 PMID: 24841273
Buchdunger Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 1996 PMID: 8548747