iMDK

Name: iMDK
Brand: Tocris Bioscience
SKU: 5126

Tocris Bioscience, part of Bio-Techne | Catalog # 5126

Citations (1)

COA / SDS

Suppressor of MDK expression; inhibits PI 3-K signaling

Key Product Details

Description:	Suppressor of MDK expression; inhibits PI 3-K signaling
Chemical Name:	3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	376.4

View Full Technical Details for iMDK

Technical Data
Citations

Biological Activity for iMDK

iMDK is a suppressor of endogenous midkine (MDK) expression. Inhibits PI 3-K signaling in H441 lung adenocarcinoma cells. Selectively attenuates growth of MDK-expressing cancer cells. Induces apoptosis in H441 cells and suppresses growth of H441 cell xenografts in mice.

Technical Data for iMDK

M. Wt	376.4
Formula	C₂₁H₁₃FN₂O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	881970-80-5
PubChem ID	15991416
InChi Key	IWFKQTWYILKFGE-UHFFFAOYSA-N
Smiles	FC(C=C5)=CC=C5CC4=CN1C(S4)=NC(C(C(O3)=O)=CC2=C3C=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for iMDK

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.88	5

Preparing Stock Solutions for iMDK

The following data is based on the product molecular weight 376.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	53.13 mL	265.67 mL	531.35 mL
0.25 mM	10.63 mL	53.13 mL	106.27 mL
0.5 mM	5.31 mL	26.57 mL	53.13 mL
2.5 mM	1.06 mL	5.31 mL	10.63 mL

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References for iMDK

References are publications that support the biological activity of the product.

Hao Inhibition of the growth factor MDK/Midkine by a novel small molecule compound to treat non-small cell lung cancer. PLoS ONE 2013 PMID: 23976985